I think this hotel located on the Ohio River's north shore offers the best view of the Louisville riverfront at night.
AAA Inspector Notes
Many guest rooms command a splendid view of the Ohio River and downtown Louisville skyline. The guest rooms feature illuminated double closets and the bathrooms have makeup mirrors. If you wish to stay here during Thunder Over Louisville, the annual fireworks show that precedes the Kentucky Derby, make your reservations well in advance.
Smoke free premises. 180 units. 10 stories, interior corridors.