Garst Museum and The National Annie Oakley Center is at 205 N. Broadway (SR 118N); entrance is through the Garst House, which was built in 1852. The museum complex features six separate but connected buildings. The Annie Oakley Center houses an extensive exhibit dedicated to the sharpshooter. Other exhibits focus on Native American history, the Treaty of Greene Ville, and broadcast journalism pioneer and nearby Woodington native Lowell Thomas.
There is a pioneer wing, an exhibit depicting a village of circa 1890-1930 shops, rooms furnished with American antiques, and a large collection of Currier and Ives works. The Darke County Research Center is housed here as well.