Cathedral (Catedral) is on the e. side of Plaza de la Independencia, opposite the Government Palace. Much of the stone used in its construction came from the ruined buildings of T'hó, the ancient Mayan city upon which Mérida was built. The interior is stark, in marked contrast to the lavish decoration of other Mexican colonial churches. One painting, hanging over a side door to the right of the main altar, depicts a meeting between the Spanish and the Xiu Indians.
To the left is a chapel containing a replica of the Christ of the Blisters (Cristo de las Ampollas), an image of Christ carved from a tree that was said to be struck by lightning but did not burn; it survived a fire in another church and was brought to the cathedral in 1645.